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James Hewett

James Hewett


Associate Professor
Department of Biology

jhewett@syr.edu

350 Life Sciences Complex
315.443.9613


Research Interests

Neuroscience and central nervous system neurobiology and pathology, neuromodulators and epilepsy, arachidonic acid metabolism and cyclooxygenase-2, cytokines and interleukin-1β, signal transduction and gene expression, animal models, transgenic mice, cell culture, pharmacology.

Education

  • Ph.D., Pharmacology and Toxicology, Michigan State University (1991)
  • B.S., Microbiology, Michigan State University (1986)

Courses



BIO 457
- Principles of Human Toxicology

College of Arts and Sciences

3 credit(s) At least 1x fall or spring


Crosslisted with: FSC 457
Double Numbered with: BIO 657
This course examines key aspects of human toxicology, including dose-response relationships, absorption, distribution, biotransformation, elimination, toxicokinetics, molecular mechanisms of toxicity, pesticides, metals, and toxic responses in specific organ systems. Additional work required of graduate students.
PREREQ: BIO 327 AND CHE 275 AND MAT 285



BIO 444 - Seminar in Neurotoxicology

College of Arts and Sciences

3 credit(s) At least 1x fall or spring


Double Numbered with: BIO 644
Examination of the mechanisms and consequences of toxicity of poisons in the central and peripheral nervous systems with a focus on the primary research literature. Additional work is required of graduate students.
PREREQ: BIO 211

Selected Publications

  • Uliasz, T.F., Hamby, M.E.(*), Jackman, N.A.(*), Hewett, J.A., and Hewett, S.J. Generation of primary astrocyte cultures devoid of contaminating microglia. Methods Mol. Biol. 814: 61-79, 2012.
  • Hewett J.A. and Hewett S.J. Induction of nitric oxide synthase-2 expression and measurement of nitric oxide production in enriched primary cortical astrocyte cultures. Methods Mol. Biol. 814: 251-263, 2012.
  • Claycomb, R.J.(*), Hewett, S.J., and Hewett, J.A. Anticonvulsant properties of endogenous interleukin-1β: possible contribution of cyclooxygenase-2. Neurobiol. Dis., 45:234-42, 2012.
  • Claycomb, R.J.(*), Hewett, S.J., and Hewett, J.A. Characterization of the effect of oral rofecoxib treatment on PTZ-induced acute seizures and kindling. Epilepsia 52:273-283, 2011.
  • Hamby, M.E.(*), Hewett, J.A., and Hewett, S.J. Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression. Glia 58:1282-1291, 2010.
  • Hewett, J.A. Determinants of regional and local diversity within the astroglial lineage of the normal central nervous system. J. Neurochem. 110:1717-1736, 2009. (REVIEW)
  • Hamby, M.E., Gragnolati, A.R.(*), Hewett, S.J., Hewett, J.A. TGFbeta1 and TNFalpha potentiates nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2. Neurochem. Int. 52:962-71, 2008.
  • Hamby, M.E.(*), Hewett, J.A., Hewett, S.J. TGF-beta1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and nitric oxide synthase-2 gene expression in a stimulus-independent manner. Prostaglandins Other Lipid Mediat. 85:115-24, 2008.
  • Hewett, S.J., Silakova, J.M., and Hewett, J.A. Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration. J. Pharmacol. Exp. Ther. 319:1219-1224, 2006.
  • Hamby, M.E.(*), Hewett, S.J., and Hewett, J.A. Purification of primary astrocyte cultures: A rapid procedure for the removal of microglia. J. Neurosci. Methods 150:128-137, 2006.
  • Hamby, M.E.(*), Hewett, J.A., Hewett, S.J. TGF-b1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS-2. Glia 54:566-577, 2006.
  • Hewett, S.J., Bell, S.C. and Hewett, J.A. Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system. Pharmacol. Ther. 112:335-357, 2006. (REVIEW)
  • Silakova, J.M., Hewett, J.A., and Hewett, S.J. Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window. J. Pharmacol. Exp. Ther. 309:1060-1066, 2004.
  • Hewett, S.J., Uliasz, T.F., Vidwans, A.S., and Hewett, J.A. Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J. Pharmacol. Exp. Ther. 293:417-425, 2000.
  • Hewett, J.A., Hewett, S.J., Winkler, S., and Pfeiffer, S.E. Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia. J. Neurosci. Res. 56:189-198, 1999.
  • Hewett, J.A. and Roth, R.A. The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria. J. Pharmacol. Exp. Ther. 272:53-62, 1995.
  • Hewett, J.A., Jean, P.A., Kunkel, S.L., and Roth, R.A. Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury. Am. J. Physiol. 265:G1011-1015, 1993.
  • Hewett, J.A. and Roth, R.A. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides. Pharmacol. Rev. 45:382-411, 1993. (REVIEW)
  • Hewett, J.A., Schultze, A.E., VanCise, S.(*), and Roth, R.A. Neutrophil depletion protects against liver injury from bacterial endotoxin. Lab. Invest. 66:347-361, 1992.

(*) mentored student

Recent Abstracts

  • Warnecke, A. (*), Schuch, K. (*), Gladstone-Helak, M., Hassett, J., Hewett, J.A. Maternal exposure to a DDT-like environmental contaminant during gestation predisposes adult offspring to seizures. American Society for Neuroscience, #PTW01-07, 2016.
  • Groden, P.J.(*), Gong, Y.(*), Wang, W.(*), Gladstone, M.B., and Hewett, J.A. Transgenic approaches to induce overexpression of cyclooxygenase-2 in discrete neuronal subpopulations of the brain. Am Soc Neurochem, #PS09, 2014.
  • Gong, Y.(*), Wang, W.(*), and Hewett, J.A. Developmental and NMDA receptor-dependent mechanisms contribute to changes in expression of prostaglandin E synthase isozymes in cultures of cortical neurons. Soc Neurosci, #231.17, 2013.
  • Hewett, J.A., Katrin Andreasson, and Hewett, S.J. Transgenic over-expression of cyclooxygenase-2 (COX-2) in neurons suppresses pentylenetetrazole (PTZ)-induced acute seizure activity and kindling acquisition. Am Epilepsy Soc, #1.015, 2010.

(*) mentored student